Trancription factors play a central role in an organism by responding to the various stimuli in the external environment and regulating the expression of specific set of genes. In a simple organism like E. coli, we have identified 271 transcription factors and have studied the protein families and the domain architecture of the transcription factors. The supplementary material contains information about the individual transcription factors which have been identified, with searchable information about the domain architecture, protein function, etc

M. Madan Babu
Sarah A. Teichmann
MRC Laboratory of Molecular Biology, Hills Road, Cambridge - CB2 2QH, UK