CoSMoS is a tool to identify highly conserved sequence motifs, to find regions suitable for mutational studies in functional analyses and to predict important structural features in Escherichia coli K12 proteins. CoSMoS provides a precomputed set of multiple sequence alignments for each individual E. coli protein with all of its homologues in the RefSeq database. From its vast set of evolutionary data it calculates information about the significance of sequence motifs together with information on the conservation of each of the more than 1.3 million amino acids encoded in the E. coli genome.

responsible: (Lars Leichert)